Infección Nosocomial: situación en España
DOI:
https://doi.org/10.37536/RIECS.2023.8.1.365Keywords:
Infección nosocomial, Neumonía, Bacteriemia, Bacteriemia relacionada con el catéter, Infección de piel y partes blandas, Infección de la herida quirúrgica, Infección por Clostidioides difficile, COVID-19, Coste asistencial, IRASAbstract
Las infecciones Relacionadas con la Asistencia Sanitaria (IRAS) afectan a un 5-10% de todos los hospitalizados, cifras que con frecuencia no incluyen las adquiridas fuera del medio hospitalario pero en relación con procedimientos para el cuidado de la salud. Las más importantes son la Infección Urinaria relacionada con el catéter urinario (CAUTI), la bacteriemia nosocomial, habitualmente causada por infección de catéteres endovasculares, la infección respiratoria, la de piel y tejidos blandos, encabezada por la infección del sitio quirúrgico y la diarrea asociada a C. difficile. Los microorganismos causantes van desde los virus a los parásitos pero son las bacterias y en segundo lugar los hongos los más frecuentemente causales de infección nosocomial. La resistencia a antimicrobianos de muchos de estos agentes es un motivo más de preocupación. La pandemia de COVID-19 ha venido a deteriorar las medidas de control de las infecciones nosocomiales y a deteriorar sus cifras. España, según datos del estudio EPINE, tiene cifras de IRAS que podemos considerar aceptables pero que testimonian que no hemos mejorado en los últimos 10 años. Finalmente, y pese a las dificultades de cuantificarlo, el coste económico de estas infecciones es astronómico y puede estimarse para nuestro País por encima d ellos 1.000 millones de euros
References
Haque M, Sartelli M, McKimm J, Abu Bakar M. Health care-associated infections - an overview. Infect Drug Resist. 2018;11:2321-33.
Klavs I, Bufon Luznik T, Skerl M, Grgic-Vitek M, Lejko Zupanc T, Dolinsek M, et al. Prevalance of and risk factors for hospital-acquired infections in Slovenia-results of the first national survey, 2001. J Hosp Infect. 2003;54(2):149-57.
Gómez-De Rueda F, Martinez-Nogueras R, Tena-Sempere ME, Elosegui-Horno I, Robles-Rodríguez L, Horno-Ureña F. Epidemiological aspects and prevalence study of nosocomial infections in a general hospital of specialties: retrospective analysis 2012-2017. Eur J Hosp Pharm. 2019;26(6):339-42.
Suetens C, Latour K, Kärki T, Ricchizzi E, Kinross P, Moro ML, et al. Prevalence of healthcare-associated infections, estimated incidence and composite antimicrobial resistance index in acute care hospitals and long-term care facilities: results from two European point prevalence surveys, 2016 to 2017. Euro Surveill. 2018;23(46).
Stewart S, Robertson C, Pan J, Kennedy S, Dancer S, Haahr L, et al. Epidemiology of healthcare-associated infection reported from a hospital-wide incidence study: considerations for infection prevention and control planning. J Hosp Infect. 2021;114:10-22.
Sociedad Española de Medicine Preventiva Salud Pública y Gestión Sanitaria. Encuesta de Prevalencia de infecciones relacionadas con la asistencia sanitaria y uso de antimicrobianos en hospitales de agudos en España 2012-2021.
Klevens RM, Edwards JR, Richards CL, Jr., Horan TC, Gaynes RP, Pollock DA, et al. Estimating health care-associated infections and deaths in U.S. hospitals, 2002. Public Health Rep. 2007;122(2):160-6.
Izadi N, Eshrati B, Etemad K, Mehrabi Y, Hashemi-Nazari SS. Rate of the incidence of hospital-acquired infections in Iran based on the data of the national nosocomial infections surveillance. New Microbes New Infect. 2020;38:100768.
Nuckchady DC. Incidence, Risk Factors, and Mortality From Hospital-Acquired Infections at a Hospital in Mauritius. Cureus. 2021;13(11):e19962.
Allegranzi B, Bagheri Nejad S, Combescure C, Graafmans W, Attar H, Donaldson L, et al. Burden of endemic health-care-associated infection in developing countries: systematic review and meta-analysis. Lancet. 2011;377(9761):228-41.
Vincent JL. Nosocomial infections in adult intensive-care units. Lancet. 2003;361(9374):2068-77.
Eriksen HM, Iversen BG, Aavitsland P. Prevalence of nosocomial infections in hospitals in Norway, 2002 and 2003. J Hosp Infect. 2005;60(1):40-5.
Magill SS, Edwards JR, Bamberg W, Beldavs ZG, Dumyati G, Kainer MA, et al. Multistate point-prevalence survey of health care-associated infections. N Engl J Med. 2014;370(13):1198-208.
Centers for Disease Control. Catheter-associated Urinary Tract Infections (CAUTI). Disponible en: https://wwwcdcgov/hai/ca_uti/utihtml. 2015.
Iacovelli V, Gaziev G, Topazio L, Bove P, Vespasiani G, Finazzi Agrò E. Nosocomial urinary tract infections: A review. Urologia. 2014;81(4):222-7.
Mengistu DA, Alemu A, Abdukadir AA, Mohammed Husen A, Ahmed F, Mohammed B. Incidence of Urinary Tract Infection Among Patients: Systematic Review and Meta-Analysis. Inquiry. 2023;60:469580231168746.
Drugeon B, Guenezan J, Pichon M, Devos A, Fouassin X, Neveu A, et al. Incidence, complications, and costs of peripheral venous catheter-related bacteraemia: a retrospective, single-centre study. J Hosp Infect. 2023;135:67-73.
Guembe M, Pérez-Granda MJ, Capdevila JA, Barberán J, Pinilla B, Martín-Rabadán P, et al. Nationwide study on peripheral-venous-catheter-associated-bloodstream infections in internal medicine departments. J Hosp Infect. 2017;97(3):260-6.
Pérez-Granda MJ, Carrillo CS, Rabadán PM, Valerio M, Olmedo M, Muñoz P, et al. Increase in the frequency of catheter-related bloodstream infections during the COVID-19 pandemic: a plea for control. J Hosp Infect. 2022;119:149-54.
Rockholt MM, Agrell T, Thorarinsdottir H, Kander T. Sustained low catheter related infection (CRI) incidence in an observational follow-up study of 9924 catheters using automated data scripts as quality assurance for central venous catheter (CVC) management. Infect Prev Pract. 2023;5(2):100273.
Smit JM, Exterkate L, van Tienhoven AJ, Haaksma ME, Heldeweg MLA, Fleuren L, et al. incidence, risk factors, and outcome of suspected central venous catheter-related infections in critically ill covid-19 patients: a multicenter retrospective cohort study. Shock. 2022;58(5):358-65.
Pérez-Granda MJ, Barrio JM, Muñoz P, Hortal J, Rincón C, Rabadán PM, et al. Ethanol lock therapy (E-Lock) in the prevention of catheter-related bloodstream infections (CR-BSI) after major heart surgery (MHS): a randomized clinical trial. PLoS One. 2014;9(3):e91838.
Chen X, Liang M. A Meta-Analysis of Incidence of Catheter-Related Bloodstream Infection with Midline Catheters and Peripherally Inserted Central Catheters. J Healthc Eng. 2022;2022:6383777.
Gonçalves-Pereira J, Mergulhão P, Nunes B, Froes F. Incidence and impact of hospital-acquired pneumonia: a Portuguese nationwide four-year study. J Hosp Infect. 2021;112:1-5.
Kumar ST, Yassin A, Bhowmick T, Dixit D. Recommendations From the 2016 Guidelines for the Management of Adults With Hospital-Acquired or Ventilator-Associated Pneumonia. P t. 2017;42(12):767-72.
Klompas M, Branson R, Cawcutt K, Crist M, Eichenwald EC, Greene LR, et al. Strategies to prevent ventilator-associated pneumonia, ventilator-associated events, and nonventilator hospital-acquired pneumonia in acute-care hospitals: 2022 Update. Infect Control Hosp Epidemiol. 2022;43(6):687-713.
Fernández-Cruz A, Ortega L, García G, Gallego I, Álvarez-Uría A, Chamorro-de-Vega E, et al. Etiology and Prognosis of Pneumonia in Patients with Solid Tumors: A Prospective Cohort of Hospitalized Cases. Oncologist. 2020;25(5):e861-e9.
European Centre for Disease Prevention and Control. Healthcare-associated infections: surgical site infections - Annual Epidemiological Report for 2017. Disponible en: https://wwwecdceuropaeu/en/publications-data/healthcare-associated-infections-surgical-site-infections-annual-1. 2017.
Wan YI, Patel A, Achary C, Hewson R, Phull M, Pearse RM. Postoperative infection and mortality following elective surgery in the International Surgical Outcomes Study (ISOS). Br J Surg. 2021;108(2):220-7.
Reigadas E, Bouza E, Olmedo M, Vázquez-Cuesta S, Villar-Gómara L, Alcalá L, et al. Faecal microbiota transplantation for recurrent Clostridioides difficile infection: experience with lyophilized oral capsules. J Hosp Infect. 2020;105(2):319-24.
Bouza E, Aguado JM, Alcalá L, Almirante B, Alonso-Fernández P, Borges M, et al. Recommendations for the diagnosis and treatment of Clostridioides difficile infection: An official clinical practice guideline of the Spanish Society of Chemotherapy (SEQ), Spanish Society of Internal Medicine (SEMI) and the working group of Postoperative Infection of the Spanish Society of Anesthesia and Reanimation (SEDAR). Rev Esp Quimioter. 2020;33(2):151-75.
Reigadas E, van Prehn J, Falcone M, Fitzpatrick F, Vehreschild M, Kuijper EJ, et al. How to: prophylactic interventions for prevention of Clostridioides difficile infection. Clin Microbiol Infect. 2021;27(12):1777-83.
van Prehn J, Reigadas E, Vogelzang EH, Bouza E, Hristea A, Guery B, et al. European Society of Clinical Microbiology and Infectious Diseases: 2021 update on the treatment guidance document for Clostridioides difficile infection in adults. Clin Microbiol Infect. 2021;27 Suppl 2:S1-s21.
Fürnkranz U, Walochnik J. Nosocomial Infections: Do Not Forget the Parasites! Pathogens. 2021;10(2).
Aloke C, Achilonu I. Coping with the ESKAPE pathogens: Evolving strategies, challenges and future prospects. Microb Pathog. 2023;175:105963.
Vázquez-López R, Solano-Gálvez SG, Juárez Vignon-Whaley JJ, Abello Vaamonde JA, Padró Alonzo LA, Rivera Reséndiz A, et al. Acinetobacter baumannii Resistance: A Real Challenge for Clinicians. Antibiotics (Basel). 2020;9(4).
Kunz Coyne AJ, El Ghali A, Holger D, Rebold N, Rybak MJ. Therapeutic Strategies for Emerging Multidrug-Resistant Pseudomonas aeruginosa. Infect Dis Ther. 2022;11(2):661-82.
Szabó S, Feier B, Capatina D, Tertis M, Cristea C, Popa A. An Overview of Healthcare Associated Infections and Their Detection Methods Caused by Pathogen Bacteria in Romania and Europe. J Clin Med. 2022;11(11).
Gerace E, Mancuso G, Midiri A, Poidomani S, Zummo S, Biondo C. Recent Advances in the Use of Molecular Methods for the Diagnosis of Bacterial Infections. Pathogens. 2022;11(6).
Okafor CM, Clogher P, Olson D, Niccolai L, Hadler J. Trends in and Risk Factors for Recurrent Clostridioides difficile Infection, New Haven County, Connecticut, USA, 2015-2020. Emerg Infect Dis. 2023;29(5):877-87.
Thomas-Rüddel DO, Schlattmann P, Pletz M, Kurzai O, Bloos F. Risk Factors for Invasive Candida Infection in Critically Ill Patients: A Systematic Review and Meta-analysis. Chest. 2022;161(2):345-55.
Osei Sekyere J. Candida auris: A systematic review and meta-analysis of current updates on an emerging multidrug-resistant pathogen. Microbiologyopen. 2018;7(4):e00578.
Ledoux MP, Herbrecht R. Invasive Pulmonary Aspergillosis. J Fungi (Basel). 2023;9(2).
Gaffney S, Kelly DM, Rameli PM, Kelleher E, Martin-Loeches I. Invasive Pulmonary Aspergillosis in the Intensive Care Unit: Current Challenges and Best Practices. Apmis. 2023.
Egger M, Bellmann R, Krause R, Boyer J, Jakši? D, Hoenigl M. Salvage Treatment for Invasive Aspergillosis and Mucormycosis: Challenges, Recommendations and Future Considerations. Infect Drug Resist. 2023;16:2167-78.
World Health Organization. Report on the Burden of Endemic Health Care-Associated Infection Worldwide. Disponibcle en https://appswhoint/iris/bitstream/handle/10665/80135/9789241501507_engpdf.
Advani SD, Sickbert-Bennett E, Moehring R, Cromer A, Lokhnygina Y, Dodds-Ashley E, et al. The Disproportionate Impact of Coronavirus Disease 2019 (COVID-19) Pandemic on Healthcare-Associated Infections in Community Hospitals: Need for Expanding the Infectious Disease Workforce. Clin Infect Dis. 2023;76(3):e34-e41.
Vázquez-Cuesta S, Olmedo M, Reigadas E, Alcalá L, Marín M, Muñoz P, et al. Clostridioides difficile infection epidemiology and clinical characteristics in COVID-19 pandemic. Front Med (Lausanne). 2022;9:953724.
Scott RD. The DirecT MeDical costs of Healthcare-Associated Infections in U.S. Hospitals and the Benefits of Prevention. Disponible en: https://wwwcdcgov/hai/pdfs/hai/scott_costpaperpdf. 2009.