Visión actual de la terapia con células CAR-T
DOI:
https://doi.org/10.37536/RIECS.2022.7.1.312Keywords:
Terapia CAR, Receptor antígeno quimérico, Síndrome liberación citoquinasAbstract
La terapia con células T portadoras de antígeno quimérico (CAR), es una forma de inmunoterapia adoptiva para neoplasias. Los resultados obtenidos con formas refractarias de Leucemia Aguda Linfoblástica (LLA) y Linfoma no Hodgkin han permitido confirmar esta modalidad terapéutica en neoplasias hematológicas mediante CAR dirigidas al CD19 y se prevé la ampliación de su uso tanto en onco-hematología como en tumores sólidos con el desarrollo de nuevos CAR. Las limitaciones del tratamiento son la toxicidad asociada a un síndrome de liberación de citoquinas y neurotoxicidad y la limitación de la duración de la respuesta. En la actualidad se está a la búsqueda de estrategias que mejoren los resultados actuales, disminuyendo las complicaciones y prolongando la duración de SLE.
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